Dr. Hulkar Mamayusupova, PhD

Professor

Department: Medical School

Office: 242, Avicenna Hall

Email: h.mamayusupova[at]akfauniversity.org

Resume

  • Fixed-term teacher in Biomedical Science University of Essex – May 2021-August 2021

  • Research Associate, University of East Anglia – May 2020-October 2021

  • Postdoctoral Research, Associate University of Essex – July 2018- ongoing

  • PhD Molecular Medicine, University of Essex – 2014

  • MPhil, University of Essex – 2009

  • BSc Biochemistry (Cum Laude), Hartiwck College, Oneonta, NY, USA – 2004

Research Interest

  • Molecular mechanims of Breast Cancer and Glioblastoma

  • Transcription factor, CTCF, and its interaction with RNA Polymerase II in gene regulation

  • Role of anticholinergic drug burden in cognitive impairment and dementia

Teaching

  • Bioinformatics — AKFA, Fall 2021

  • Fixed-term lecturer, Biochemistry —Sprint, 2021, U of Essex

  • TA, Cancer Biology — Spring, 2021 University of Essex

  • TA, Genomics — Fall, 2020, University of Essex

Publications

  1. R. M. Sanghavi, T. A. Pana, H. Mamayusupova, I. Maidment, C. Fox, S. M. Boekholdt, M. A. Mamas, N. J. Wareham, K. Khaw and P. K. Myint. Higher anticholinergic burden from medications is associated with significant increase in markers of inflammation in the EPIC-Norfolk prospective population-based cohort study. British Journal of Clinical Pharmacology, 2021 (under review). ID: EJEP-D-21-00558

  2. C. Fleetwood, M. Salehi, R. Ward, H. Mamayusupova, A. Secchi, S. Coulton, I. D. Maidment, P. K. Myint, C. Fox and S. Sami. A data driven approach to anticholinergic burden quantification. Artificial Intelligence in Medicine, 2021 (under review)

  3. H. Mamayusupova, M. Tolia, A.Secchi, M. Salehi, J. Cartwright, R. Ward, C. Skeen, S. Sami, I. D. Maidment, P. K. Myint, S. Coulton and C. Fox. Systematic review and narrative synthesis of antipsychotic drugs with anticholinergic effect on immune and metabolic biomarkers. Neuropsychopharmacology (manuscript in preparation).

  4. H. Mamayusupova, D. Azman, V. Balakrishnan, S. Shamsuddin, P. Laissue, S. Kang, I. Chernukhin, D. Loukinov, V. Lobanenkov, V. B. Teif and E. Klenova. Disrupting the interaction of CTCF and RNA Polymerase II affects chromatin distribution, cell survival and proliferation, transcription and insulator function (in preparation).

  5. G.J. Thorn, C. T. Clarkson, A. Rademacher, H. Mamayusupova, G. Schotta, K. Rippe and V.B. Teif. DNA sequence-dependent formation of heterochromatin nanodomains. bioRxiv 2020.12.20.423673; doi: https://doi.org/10.1101/2020.12.20.423673. Nature Genetics (under review).

  6. C. T. Clarkson, E. A. Deeks, R. Samarista, H. Mamayusupova, V. B. Zhurkin and V.B. Teif. CTCF-dependent chromatin boundaries formed by asymmetric nucleosome arrays with decreased linker length. Nucleic Acids Research, 47, 11181–11196.

Awards

  • Interdisciplinary School in 3D Genomics: From experiments to models and back. France, 2020